Thangamani Lab

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Thangamani Lab

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Publications

 PubMed Link / Google Scholar Page 

                                                                              2023


  • Balakumar A, Bernstein D and Thangamani S*. The adhesin SCF1 mediates Candida auris Colonization.

          Trends in Microbiology  (*Corresponding author) 

  • Carty J, Chowdhary A, Bernstein D* and Thangamani S*. Tools and Techniques to Identify, Study and Control Candida auris Colonization. PLOS Pathogens. (* Corresponding authors) 
  • Datta A, Das D, Nett J, Vyas J, Lionakis MS and Thangamani S*. Differential Skin Immune Responses in Mice Intradermally Infected with Candida auris and Candida albicans. Microbiology Spectrum.  (*Corresponding author) 
  • Das D, HogenEsch H and Thangamani S*. Intestinal colonization with Candida auris and mucosal immune response in mice treated with cefoperazone oral antibiotic. Frontiers in Immunology 

           (*Corresponding author) 

  • Tharp B, Zheng R, Bryak G, Litvintseva A, Hayden M, Chowdhary A* and Thangamani S*.  Role of Microbiota in the Skin Colonization of Candida auris. mSphere (* Corresponding authors) 

  

                                                                              2022


  • Jaffey JA*, Okwumabua O, Graves TK, Al-Nakkash L, Monasky R, Wilson A, Thangamani S*.  Evaluation of Candida spp. and Other Fungi in Feces from Dogs with Naturally Occurring Diabetes Mellitus. Vet Sci (* Corresponding authors) 
  • Abhishek Datta, Juan F Hernandez-Franco, Sungtae Park, Matthew R. Olson, Harm HogenEsch and Shankar Thangamani*. Bile Acid Regulates Mononuclear Phagocytes and T helper 17 cells to Control Candida albicans in the Intestine. Journal of Fungi (* Corresponding author) 
  • Hannah Dowdy, Raju Suresh Kumar, Abdulrahman Almansour, Natarajan Arumugam, Shatha IbrahimAlaqeel, Thangamani S*. Discovery of spirooxindole-pyrrolidine heterocyclic hybrids with potent antifungal activity against fungal pathogens. Pathogens and Disease (* Corresponding author)   

                                                                             2021

 

  • Thangamani S*, Ross Monasky,  Jung Keun Lee,  Vijay Antharam,  Harm HogenEsch,  Tony R. Hazbun,  Yan Jin,  Haiwei Gu  and Grace L. Guo. Bile Acid Regulates the Colonization and Dissemination of Candida albicans from the Gastrointestinal Tract by Controlling Host Defense System and Microbiota. Journal of Fungi (* Corresponding author)  
  • Mona A El-Kaitlin C Hampton, Alexis Carey, Sarah Kassam, Alyssa Garner, George L Donati, Thangamani S, Sargurunathan Subashchandrabose. A genome-wide screen reveals the involvement of enterobactin-mediated iron acquisition in Escherichia coli survival during copper stress. Metallomics
  • Saif Hameed, Sandeep Hans, Shweta Singh, Ruby Dhiman, Ross Monasky, Ramendra Pati Pandey, Thangamani S, and Zeeshan Fatima. Revisiting the Vital Drivers and Mechanisms of β-Glucan Masking in Human Fungal Pathogen, Candida albicans. Pathogens
  • Mona A El-Zamkan, Bassma A Hendy, Hassan Mahmoud Diab, Najat Marraiki, Gaber El-Saber Batiha, Hani Saber, Waleed Younis, Thangamani S*, Khalid J Alzahrani, Ahmed Shaban Ahmed*. Control of Virulent Listeria monocytogenes Originating from Dairy Products and Cattle Environment Using Marine Algal Extracts, Silver Nanoparticles Thereof, and Quaternary Disinfectants. Infection and Drug Resistance (* Corresponding authors)
  •  Saif Hamee, Sandeep Hans, Ross Monasky, Thangamani S*,, Zeeshan Fatima*.  Understanding Human Microbiota Offers Novel and Promising Therapeutic Options against Candida Infections. Pathogens (* Corresponding authors)  

                                                                      2020


  • Ross Monasky, Sonia Villa,  Thangamani S*.  An Ex vivo Assay to Study Candida albicans Hyphal Morphogenesis in the Gastrointestinal Tract.  Journal of Visualized Experiments (JoVE) (* Corresponding author) 
  • Sonia Villa, Mohammad Hamideh, Anthony Weinstock, Mohammad N Qasim, Tony R Hazbun, Adnane Sellam, Aaron D Hernday,  Thangamani S*. Transcriptional control of hyphal morphogenesis in Candida albicans. FEMS Yeast Research. (* Corresponding author) 
  •  Lawson S, Arumugam N*, Abdulrahman I. Almansour, Kumar R ,  Thangamani S*. Dispiropyrrolidine Tethered Piperidone Heterocyclic Hybrids With Broad-Spectrum Antifungal Activity Against Candida Albicans and Cryptococcus Neoformans. Bioorganic Chemistry (* Corresponding authors) 
  •  Gutierrez D, Weinstock A, Antharam VC, Gu H, Jasbi P, Shi X, Dirks B, Krajmalnik-Brown R, Maldonado J, Guinan J, Thangamani S*.  Antibiotic-induced gut metabolome and microbiome alterations increase the susceptibility to Candida albicans colonization in the gastrointestinal tract.  FEMS Microbiology Ecology(* Corresponding author)   

2019


  • Weinstock A, Arumugam N*, Abdulrahman I. Almansour, Kumar R,  Thangamani S*. Discovery of diazahexa/hepta cyclic cage-like systems compounds with broad-spectrum antifungal activity against Candida and Cryptococcus species. RSC Advances (* Corresponding authors)  
  •  Guinan J, Wang S, Hazbun TR, Yadav H,  Thangamani S*.  Antibiotic-induced decreases in the levels of microbial-derived short-chain fatty acids correlate with increased gastrointestinal colonization of Candida albicans. Scientific Reports (* Corresponding author)  
  •  Bolous M, Arumugam N* , Almansour AI, Suresh Kumar R, Maruoka K, Antharam VC, Thangamani S*. Broad-spectrum antifungal activity of spirooxindolo-pyrrolidine tethered indole/imidazole hybrid heterocycles against fungal pathogens.  Bioorganic and Medicinal Chemistry Letters (* Corresponding authors)   
  •  Villa P, Arumugam N* , Almansour AI, Suresh Kumar R, Mahalingam SM, Maruoka K, Thangamani S*. Benzimidazole tethered pyrrolo[3,4-b]quinoline with broad-spectrum activity against fungal pathogens.  Bioorganic and Medicinal Chemistry Letters (* Corresponding authors)    

2018


  • Guinan J, Thangamani S*.  Antibiotic-induced alterations in taurocholic acid levels promote gastrointestinal colonization of Candida albicans. FEMS Microbiology Letters  (* Corresponding author)  
  •  Guinan J,  Villa P,   Thangamani S*.  Secondary bile acids inhibit the growth and morphogenesis of Candida albicans. Pathogens and Disease (* Corresponding author)    

Publications Prior to 2018


  • Thangamani S, M. Maland, H. Mohammad, P. Pascuzzi, L. Avramova, C. Koehler, T. R. Hazbun and M. N. Seleem. Repurposing approach identifies auranofin with broad-spectrum antifungal activity that targets Mia40-Erv1 pathway, Frontiers in Cellular and Infection Microbiology (2017)
  • Thangamani S, H. E. Eldesouky, H. Mohammad, P. Pascuzzi, L. Avramova, T. R. Hazbun and M. N. Seleem. Ebselen exerts antifungal activity by regulating glutathione (GSH) and reactive oxygen species (ROS) production in fungal cells. BBA- General Subjects (2017)
  • Thangamani S, Mohammad H, Abushahba MF, Hamed MI, Sobreira TJ, Hedrick VE, Paul LN, Seleem MN. Antibacterial activity and mechanism of action of auranofin against multi-drug resistant bacterial pathogens. Scientific Reports (2016) 
  • Thangamani S, Mohammad H, Abushahba MF, Hamed MI, Sobreira TJ, Hedrick VE, Paul LN, Seleem MN. Repurposing auranofin for the treatment of cutaneous staphylococcal infections. International Journal of Antimicrobial Agents and Chemotherapy (2016) 
  • Abushahba MF, Mohammad H, Thangamani S, Hussein AA, Seleem MN. Impact of different cell penetrating peptides on the efficacy of antisense therapeutics for targeting intracellular pathogens. Scientific Reports (2016) 
  • Thangamani S, Mohammad H, Abushahba MF, Hamed MI, Sobreira TJ, Hedrick VE, Paul LN, Seleem MN. Exploring simvastatin, an antihyperlipidemic drug, as a potential topical antibacterial agent. Scientific Reports (2015) 
  • Thangamani S, Nepal M, Chmielewski J, Seleem MN. Antibacterial activity and therapeutic efficacy of Fl-P(R)P(R)P(L)-5, a cationic amphiphilic polyproline helix, in a mouse model of staphylococcal skin infection. Drug Des Devel Ther (2015) 
  • Thangamani S, Younis W, Seleem MN. Repurposing celecoxib as a topical antimicrobial agent. Frontiers in Microbiology (2015) 
  • Thangamani S, Younis W, Seleem MN. Repurposing Clinical Molecule Ebselen to Combat Drug Resistant Pathogens. PLoS One (2015) 
  • Thangamani S, Younis W, Seleem MN. Repurposing ebselen for treatment of multidrug-resistant staphylococcal infections. Scientific Reports (2015) 
  • Younis W, Thangamani S, Seleem MN. Repurposing Non-Antimicrobial Drugs and Clinical Molecules to Treat Bacterial Infections Current Pharmaceutical Design (2015) 
  • Nepal M, Thangamani S, Seleem MN, Chmielewski J. Targeting intracellular bacteria with an extended cationic amphiphilic polyproline helix. Organic and Biomolecular Chemistry (2015)
  • Mohammad H, Thangamani S, Seleem MN. Antimicrobial peptides and peptidomimetics - potent therapeutic allies for staphylococcal infections. Current Pharmaceutical Design (2015)
  • Thangamani S, Mohammad H, Younis W, Seleem MN. Drug repurposing for the treatment of staphylococcal infections. Current Pharmaceutical Design (2015)
  • Thangamani S*, Kim M*, Son Y, Huang X, Kim H, Lee JH, Cho J, Ulrich B, Broxmeyer HE, Kim CH. Cutting edge: progesterone directly up regulates vitamin d receptor gene expression for efficient regulation of T cells by calcitriol. Journal of Immunology (2015). (* Co-first authors)
  • Wang C*, Thangamani S*, Kim M, Gu BH, Lee JH, Taparowsky EJ, Kim CH. BATF is required for normal expression of gut-homing receptors by T helper cells in response to retinoic acid. Journal of Experimental Medicine  (2013) (* Co-first authors) 
  • Chang J, Thangamani S, Kim MH, Ulrich B, Morris SM Jr, Kim CH. Retinoic acid promotes the development of Arg1-expressing dendritic cells for the regulation of T-cell differentiation. European Journal of Immunology (2013).